Interview with bioinformatics contributor for CureCoin, newest project in the HitBTC ecosystem

Back at the end of March we announced the start of our COVID-19 initiative, which we launched in order to help projects looking to join in the fight against the global coronavirus pandemic. We are happy to share that we were able to interview Josh Smith from CureCoin, the first project we have integrated as part of the initiative, along with a contributing scientist and bioinformatics guru working hands on with the data at the heart of the project. The first interview we will release will be with the bioinformatics and data analyst, who will remain unnamed due to ongoing restrictions applied to the scientists partaking in this research.

CureCoin got started in 2014 as part of the Folding@home project. Folding@home is an initiative backed by Stanford University that has been using a distributed computer network to collate computing power in order to study how proteins misfold themselves. Protein misfolding is a process that occurs over time in the human body due to mutations and other changes and leads to a variety of degenerative diseases.

With everything that has been happening due to the ongoing coronavirus pandemic, Folding@home has prioritized research related to COVID-19 in order to help better understand the disease and thereby come up with a cure.

HitBTC: How are proteinopathies similar between cancer, Alzheimer’s, Huntingtons and infectious diseases – how can only a few pieces of software (GROMACS, OpenMM, etc) cover such a broad range of diseases?

Contributing Scientist: Well, for sure, all diseases can vary in strains and mutations, what we know is based on current health data of individuals suffering from those diseases. There are other diseases that could cause cancer and other infectious diseases in the long term as one individual hits a certain age. Unfortunately, many disease causes rely on unknowns on whether someone inherited it, or whether it was caused by other diseases, etc. To interpret all these causes, yes in-silico modeling can provide us with certain answers to start developing therapeutics and be able to make them safe. Cells receptors and protein binding is what we are interested in the most; on whether a cancerous cell can be killed by entering through its receptors and hitting its nucleus destroying that cell, or keeping our immune cells safe by developing blockers to deactivate foreign cells to prevent killing our cells like the T-Cells, B-Cells … (immune cells) that fight for us to kill those foreign cells. Most drug bindings are emphasized to create or design blockers or inhibitors to protect our immune cells [and let them do their job]. The study of immune cells in a silico modelling is another part of informatics that helps us understand their behaviour and molecular structure when cells enter into a stressful situation.

H: How do you foresee the huge potential in combating debilitating disorders using distributed supercomputing compared to dedicated supercomputers? (cost, availability during time sharing, etc)

CS: Well yes it’s essential to utilize all the tools necessary to understand a disease, and be able to take it to the lab running experiments that will cut cost and time since using lab equipment, reagents etc are super expensive to maintain and use.

H: Folding@home is now considered to be one of the world’s most widely distributed and fastest computing systems with a speed of approximately 1.18 exaFLOPS, or 2.36 x86 exaFLOPS, allowing it to fold several proteins in the 1.5 millisecond time range. How does this compare to experimental crystallography methods of the past?

CS: This part is more for a chemist or biochemist that is using “experimental crystallography methods”. [From my experience] when developing a certain molecule, we use radiation to break bonds and to determine potency we used radioactive Iodine-125 bioassays and similar compounds – so YES having a computer modelling allows us to see the molecules folding and predict how to target those receptors better [without the need for costly, often inaccurate chemical experiments early on].

H: What is a k-factor in protein folding dynamics and molecular simulations – the factor that is used in determining Points awarded to protein folders on Folding@home?

CS: K-factor is part of what determines the PPD point value of a Folding@home Work Unit (WU). Based on Folding@home’s description, many factors go into determining a WU’s value. The kinematic and thermodynamics variables that induce difficulty in protein folding, and the scientific value resulting from a successful simulation of that molecule’s structure. Traditionally, chemists have done this all day. Dangerously! Bravo to them, and bravo for them risking their lives in those research labs! That’s one of the biggest value-adds to research in-silico simulations. [The Urey-Miller Ab initio nanoreactor experiment perhaps shows this most clearly (see also Carl Sagan on Cosmos). In 1952, scientists basically tried to create life in a jar, simulating conditions (through many permutations) that were found on earth before life arose. They were able to find some organic compounds, but the experiment was limited by equipment funding and dedicated lab time. In 2014, Folding@home was able to take the same experiment, and run it virtually on Folding@home software through thousands of permutations. They were able to find 600 unique organic compounds never seen on earth today – similar to the compounds we are just beginning to uncover hidden deep inside meteorites. It’s not “life” as we know it, but it represents life’s fundamental building blocks].

H: What novel methods do Folding@home researchers utilize to statistically analyse the dynamics of protein folding? AI is used to both generate the initial folding model, AND to analyse all the data generated by the protein folders. Why are Markov state models the preferred method for analyzing protein models?

CS: Yes, in-silico modeling is what everyone looks at first [in the FDA drug approval process] – which is essential these days. Markov modelling provides a robust understanding of specific clusters that are grouped in certain strains, mutations, or any specific characteristic that could be unknown. Markvov works well by giving a great amount of data already from that specific mRNA, cell type, receptors (e.g., ion channels), or other to classify each one as one group based on certain characteristics or variables as an identifier… depending on what you are trying to accomplish obviously, the algorithms can be tailored to characterize each given molecule.

H: As the available computational power now exceeds 1 exaflop — faster than some of the world’s top supercomputers — what kind of exploration can be done at this level? Can you explore Ion channels, protein folding time scales, etc?

CS: As more computational power we have available through distributed computing, the more “super complex systems” (like ion channels) can be explored in ways not possible less than a decade ago. Understandably, humans have the most studied, yet most complex metabolisms, and immune systems. Thus to fight diseases requires an extraordinary amount of computational power. [Even with all the available power, we are decades away from being able to fully simulate entire organs, let alone an entire human being].

H: How does the COVID-19 research compare with the Ebola virus epidemic in 2013-2016? Could you discuss the different types of viruses (positive-strand vs negative-strand RNA) and their means of transmission?

CS: These diseases are neither the same in how they are transmitted nor in the RNA they contain (a coronavirus is a single-stranded, positive-sense RNA virus, while Ebola is a single-stranded negative-sense RNA virus, so how they bind inside our cells is different). Coronavirus is a respiratory disease that can be transmitted merely through breathing the same air in close proximity of an asymptomatic patient, Ebola is a hemorrhagic fever transmitted only through contact with bodily fluids of patients who are visibly ill.

While CureCoin is the first project we have integrated via our initiative, we hope to add more projects that are trying to make a meaningful impact in the fight against the virus. In the meantime, we hope you find the interviews informative.

The HitBTC Cryptohopper Giveaway

Dear Traders,

We are teaming up with Cryptohopper to offer 1 month discount codes for their Adventurer Hopper trader package and unlimited access to the Cryptohopper Academy!

How to apply:

  1. Sign up on HitBTC.
  2. Sign up on Cryptohopper.
  3. There has to be a balance equivalent to no less than $100 (in USDT, BTC or ETH) on your account by April 20.
  4. Submit your account email to: https://cryptohopper.typeform.com/to/BDgJpU

New and existing users welcome!

We appreciate each and everyone of our users and strive to give you the best trading experience available on the market. We are very pleased that thanks to our new partnership you now have access to some unique opportunities right here on HitBTC.

Apply now and take your crypto trading to the next level!

End date: April 20th, 2020.

EDIT: Please note that this giveaway has been extended until May 1st, 2020.

Demo HitBTC is live. HitBTC launches virtual trading platform

Dear Traders,

We are pleased to announce that we have launched a demo platform where our users can try and test trading strategies for free, with a virtual balance, in real-life market conditions.

The new demo platform includes most of the features from our main platform. It also offers an exclusive margin trading feature with x5 leverage that allows users to initiate a margin trade with a requirement to commit a percentage of the total order value.

For our users’ benefit and education we added 3 trading pairs, namely:

  • EOS/USDT
  • BTC/USDT
  • EOS/BTC

The new demo platform will run separately from our main platform and will require you to sign up. Please click here to create a free account.

After you sign up, you will get a virtual demo fund of 100 USDT TST and 0.01 BTC TST to trade with.

For user convenience, our demo service will work through its own new webpage and API. We offer one of the most advanced API service solutions in the crypto space, and it works seamlessly with both algorithmic trading systems and real-time order execution.

Go ahead and test out your trading strategies today risk-free with our new demo trading platform.

Good luck!

ROOBEE Trading Contest on HitBTC

We are pleased to announce that a ROOBEE trading contest with a prize pool of 4300 USDT tokens will take place on our platform from 00:00 (UTC) on April 7th to 00:00 (UTC) on April 17th, 2020.

How to participate?

  • Trade ROOBEE on HitBTC during the contest period.
  • Sit back, relax and wait until the end of the contest to see if you won. Users will be ranked on their buy and sell trade volumes during the contest period.

Prizes and Positions

1: 1500 USDT
2: 1000 USDT
3: 700 USDT
4: 400 USDT
5: 200 USDT
6-10: 100 USDT

Good Luck and Happy Trading!

Apply now: https://hitbtc.com/trading-contest/47

Please note that we have a zero-tolerance policy towards wash trading and other unfair trading strategies. Those suspected of wash trading will be excluded from the list of winners.

HitBTC will provide support for social startups helping with the COVID-19 crisis

Dear crypto community,

In response to the outbreak and continued spread of Coronavirus affecting people all over the planet, we would like to announce that we will be doing our part at HitBTC to help out socially important crypto projects that are working to combat the disease.

To that end, we are offering platform integration for digital assets developed by projects that support healthcare activities and cutting-edge science initiatives that may need computing power donations.

To apply for HitBTC support, please send an email to team@hitbtc.com, with the following information:

– Project name
– Project website
– Brief description
– White Paper
– Project GitHub profile
– All your social media profiles

It is very important that you let us know how exactly your assets contribute to the fight against COVID-19, so please make sure to address this issue as well.

We will be accepting applications up to and including May 1st.

Times are tough for many right now, but people from all different industries and walks of life have been answering the call and doing their best to make things better. HitBTC is happy to do what we can in this time of need.

Please stay safe and healthy!

Tachyon Protocol (IPX) Trading Contest on HitBTC

We are pleased to announce that we will hold a Tachyon Protocol (IPX) trading contest on our platform with a prize pool of 216,445 IPX tokens from 00:00 (UTC) on March 24th to 00:00 (UTC) on April 7th, 2020.

How to participate?

  1. Trade IPX against BTC during the contest period.
  2. Wait until the end of the contest period to see if you won. Users will be ranked on their buy and sell trade volumes during the contest.

Prizes and Positions

1st prize – 90,000 IPX
2nd prize – 50,000 IPX
3rd prize – 30,000 IPX
4th prize – 15,000 IPX
5the prize – 10,000 IPX
6th to 10th prizes – 4289 IPX

Good luck and happy trading!

Apply now: https://hitbtc.com/trading-contest/45

Please note that we have a zero-tolerance policy towards wash trading and other unfair trading strategies. Those suspected of wash trading will be excluded from the list of winners.

DASH Trading Contest on HitBTC

We are pleased to announce that we will be holding a Dash (DASH) trading contest on our platform from 00:00 (UTC) on March 18, 2020 to 00:00 (UTC) on April 15, 2020.

Trade DASH on HitBTC for a chance to win top prizes including a selection of some of the best state-of-the-art laptops for trading as well as DASH tokens!

How to participate

  • Trade DASH against BTC during the contest period.
  • Your DASH balance at the end of the contest cannot be lower than your DASH balance at the start.

All users will be ranked in terms of their total DASH trading volume on their HitBTC account (including both Buys and Sells) during the competition period.

Prizes and Positions

1st place: will receive a free ASUS VivoBook (X571GT-BQ037) + $500 in DASH

2nd place: will win a free Dell G3 3590 + $500 in DASH

3rd to 8th places : $3,000 in DASH divided in proportion to their respective volumes

Apply now: https://hitbtc.com/trading-contest/44

Good luck and happy trading!


The 3rd Silverway (SLV) Trading Contest on HitBTC

We are excited to announce that we will hold a third SLV trading contest with a prize pool of 100,000 SLV tokens to give away to a number of lucky winners.

The contest will run from 00:00 (UTC) on March 12th to 00:00 (UTC) on March 21st, 2020.

How to take part?

Trade SLV against BTC on our platform during the contest period.
Your SLV balance at the end of the contest cannot be lower than your SLV balance at the start.
Wait to see if you were one of the lucky winners. Users will be ranked in terms of their net buys of SLV during the contest period (buys minus sells).

Prizes and Positions

Prize pool: 100,000 SLV

1st prize: 33,000 SLV
2nd prize: 22,000 SLV
3rd prize: 14,000 SLV
4th prize: 7,000 SLV
5th-10th prize: 4,000 SLV

Accumulate more SLV by showcasing your best trading skills.

Good luck and happy trading!

Apply now: https://hitbtc.com/trading-contest/43

Bonus Program from ARPA Token on HitBTC

To celebrate being added to our platform, the ARPA team will run a Bonus Program Airdrop with a prize fund of 500,000 ARPA for users who deposit ARPA on HitBTC.

That’s right. Free tokens from ARPA for those of you who deposit your ARPA tokens on our platform where you will receive an extra 1% on top of your original holdings.

Here’s how it works

  1. Create an ARPA wallet address on our platform and deposit your ARPA tokens there, the minimum amount to qualify for the bonus is 10,000 ARPA.
  2. Transfer your tokens anytime between 15:00 UTC on March 9th to 15:00 UTC on March 16th, 2020. The event will close on March 16th or as soon as the bonus pool has been utilized, whatever comes first.
  3. Wait to receive your bonus ARPA tokens. You will receive your bonus ARPA tokens via airdrop into your wallet address on HitBTC five business days after the end of the Bonus Program.

The ARPA Bonus Program Airdrop is provided by the team at ARPA Token. If you wish to participate, please note that qualifying for the Bonus Program Airdrop will be on a first-come-first-served basis.

VSYS Trading Contest on HitBTC

We are pleased to announce that we will hold a v.systems (VSYS) trading contest on our platform with a prize pool of 482,150 VSYS tokens from 00:00 (UTC) on March 1st to 00:00 (UTC) on March 16th, 2020.

How to participate?

Trade VSYS against BTC during the contest period.
Your VSYS balance at the end of the contest cannot be lower than your VSYS balance at the start.
Kick back, relax and wait until the end of the contest to see if you won. Users will be ranked on their buy and sell trade volumes during the contest period.

Prizes and Positions

1st prize: 150,000 VSYS
2nd prize: 100,000 VSYS
3rd prize: 50,000 VSYS
4th prize: 40,000 VSYS
5th prize: 30,000 VSYS
6th-10th prize: 22,430 VSYS each

Good Luck and Happy Trading!

Apply now: https://hitbtc.com/trading-contest/42